Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

References

[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). PubMed=3515319 [NCBI, ExPASy, EBI, Israel, Japan] Persico M.G., Viglietto G., Martini G., Toniolo D., Paonessa G., Moscatelli C., Dono R., Vulliamy T.J., Luzzatto L., D'Urso M.; "Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region."; Nucleic Acids Res. 14:2511-2522(1986).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT). PubMed=2428611 [NCBI, ExPASy, EBI, Israel, Japan] Martini G., Toniolo D., Vulliamy T., Luzzatto L., Dono R., Viglietto G., Paonessa G., D'Urso M., Persico M.G.; "Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase."; EMBO J. 5:1849-1855(1986).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT). PubMed=1889820 [NCBI, ExPASy, EBI, Israel, Japan] Chen E.Y., Cheng A., Lee A., Kuang W., Hillier L., Green P., Schlessinger D., Ciccodicola A., D'Urso M.; "Sequence of human glucose-6-phosphate dehydrogenase cloned in plasmids and a yeast artificial chromosome."; Genomics 10:792-800(1991).
[4]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT). DOI=10.1093/hmg/5.5.659; PubMed=8733135 [NCBI, ExPASy, EBI, Israel, Japan] Chen E.Y., Zollo M., Mazzarella R.A., Ciccodicola A., Chen C.-N., Zuo L., Heiner C., Burough F.W., Ripetto M., Schlessinger D., D'Urso M.; "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."; Hum. Mol. Genet. 5:659-668(1996).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT). Galgoczy P., Platzer M.; Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[6]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). TISSUE=Lung; DOI=10.1073/pnas.242603899; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan] Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J.M. , Marra M.A.; "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."; Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
[7]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-70. DOI=10.1016/0092-8674(89)90440-6; PubMed=2758468 [NCBI, ExPASy, EBI, Israel, Japan] Kanno H., Huang I.Y., Kan Y.W., Yoshida A.; "Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase."; Cell 58:595-606(1989).
[8]	NUCLEOTIDE SEQUENCE OF 1-70. PubMed=8466644 [NCBI, ExPASy, EBI, Israel, Japan] Kanno H., Kondoh T., Yoshida A.; "5' structure and expression of human glucose-6-phosphate dehydrogenase mRNA."; DNA Cell Biol. 12:209-215(1993).
[9]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40. DOI=10.1016/0378-1119(91)90078-P; PubMed=1874446 [NCBI, ExPASy, EBI, Israel, Japan] Toniolo D., Filippi M., Dono R., Lettieri T., Martini G.; "The CpG island in the 5' region of the G6PD gene of man and mouse."; Gene 102:197-203(1991).
[10]	PROTEIN SEQUENCE OF 1-8. TISSUE=Platelet; DOI=10.1038/nbt810; PubMed=12665801 [NCBI, ExPASy, EBI, Israel, Japan] Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.; "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."; Nat. Biotechnol. 21:566-569(2003).
[11]	NUCLEOTIDE SEQUENCE OF 40-514 (ISOFORM SHORT), AND VARIANTS MET-67 AND ASP-125. PubMed=12524354 [NCBI, ExPASy, EBI, Israel, Japan] Saunders M.A., Hammer M.F., Nachman M.W.; "Nucleotide variability at G6pd and the signature of malarial selection in humans."; Genetics 162:1849-1861(2002).
[12]	NUCLEOTIDE SEQUENCE OF 153-514 (ISOFORM SHORT). PubMed=3012556 [NCBI, ExPASy, EBI, Israel, Japan] Takizawa T., Huang I.-Y., Ikuta T., Yoshida A.; "Human glucose-6-phosphate dehydrogenase: primary structure and cDNA cloning."; Proc. Natl. Acad. Sci. U.S.A. 83:4157-4161(1986).
[13]	PROTEIN SEQUENCE OF 198-214. PubMed=3126064 [NCBI, ExPASy, EBI, Israel, Japan] Camardella L., Caruso C., Rutigliano B., Romano M., di Prisco G., Descalzi-Cancedda F.; "Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate."; Eur. J. Biochem. 171:485-489(1988).
[14]	PROTEIN SEQUENCE OF 508-514. PubMed=6696761 [NCBI, ExPASy, EBI, Israel, Japan] Descalzi-Cancedda F., Caruso C., Romano M., di Prisco G., Camardella L.; "Amino acid sequence of the carboxy-terminal end of human erythrocyte glucose-6-phosphate dehydrogenase."; Biochem. Biophys. Res. Commun. 118:332-338(1984).
[15]	ALTERNATIVE SPLICING. PubMed=2910917 [NCBI, ExPASy, EBI, Israel, Japan] Hirono A., Beutler E.; "Alternative splicing of human glucose-6-phosphate dehydrogenase messenger RNA in different tissues."; J. Clin. Invest. 83:343-346(1989).
[16]	ACETYLATION SITE ALA-1, AND MASS SPECTROMETRY. PubMed=7857286 [NCBI, ExPASy, EBI, Israel, Japan] Camardella L., Damonte G., Carratore V., Benatti U., Tonetti M., Moneti G.; "Glucose 6-phosphate dehydrogenase from human erythrocytes: identification of N-acetyl-alanine at the N-terminus of the mature protein."; Biochem. Biophys. Res. Commun. 207:331-338(1995).
[17]	REVIEW ON VARIANTS. PubMed=8364584 [NCBI, ExPASy, EBI, Israel, Japan] Vulliamy T., Beutler E., Luzzatto L.; "Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene."; Hum. Mutat. 2:159-167(1993).
[18]	PHOSPHORYLATION SITE TYR-400, AND MASS SPECTROMETRY. DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan] Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.; "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."; Nat. Biotechnol. 23:94-101(2005).
[19]	X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF VARIANT CANTON IN COMPLEX WITH NADP, AND HOMOTETRAMERIZATION. DOI=10.1016/S0969-2126(00)00104-0; PubMed=10745013 [NCBI, ExPASy, EBI, Israel, Japan] Au S.W., Gover S., Lam V.M., Adams M.J.; "Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency."; Structure 8:293-303(2000).
[20]	REVIEW ON VARIANTS. DOI=10.1002/humu.10036; PubMed=11857737 [NCBI, ExPASy, EBI, Israel, Japan] Kwok C.J., Martin A.C., Au S.W., Lam V.M.; "G6PDdb, an integrated database of glucose-6-phosphate dehydrogenase (G6PD) mutations."; Hum. Mutat. 19:217-224(2002).
[21]	VARIANT A(+) ASP-125. PubMed=3446582 [NCBI, ExPASy, EBI, Israel, Japan] Takizawa T., Yoneyama Y., Miwa S., Yoshida A.; "A single nucleotide base transition is the basis of the common human glucose-6-phosphate dehydrogenase variant A (+)."; Genomics 1:228-231(1987).
[22]	VARIANT A(-) MET-67. PubMed=2836867 [NCBI, ExPASy, EBI, Israel, Japan] Hirono A., Beutler E.; "Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-)."; Proc. Natl. Acad. Sci. U.S.A. 85:3951-3954(1988).
[23]	VARIANTS. PubMed=3393536 [NCBI, ExPASy, EBI, Israel, Japan] Vulliamy T.J., D'Urso M., Battistuzzi G., Estrada M., Foulkes N.S., Martini G., Calabro V., Poggi V., Giordano R., Town M., Luzzatto L., Persico M.G.; "Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia."; Proc. Natl. Acad. Sci. U.S.A. 85:5171-5175(1988).
[24]	VARIANTS GLN-226 AND SER-352, AND VARIANTS CNSHA CYS-386; LEU-393; ASP-409 AND PRO-438. PubMed=1611091 [NCBI, ExPASy, EBI, Israel, Japan] Beutler E., Westwood B., Prchal J.T., Vaca C.S., Bartsocas C.S., Baronciani L.; "New glucose-6-phosphate dehydrogenase mutations from various ethnic groups."; Blood 80:255-256(1992).
[25]	VARIANTS SASSARI/CAGLIARI PHE-187 AND SEATTLE HIS-281. PubMed=2912069 [NCBI, ExPASy, EBI, Israel, Japan] de Vita G., Alcalay M., Sampietro M., Cappelini M.D., Fiorelli G., Toniolo D.; "Two point mutations are responsible for G6PD polymorphism in Sardinia."; Am. J. Hum. Genet. 44:233-240(1989).
[26]	VARIANT CSNA ARG-31. PubMed=1945893 [NCBI, ExPASy, EBI, Israel, Japan] Chao L.T., Du C.S., Louie E., Zuo L., Chen E., Lubin B., Chiu D.T.; "A to G substitution identified in exon 2 of the G6PD gene among G6PD deficient Chinese."; Nucleic Acids Res. 19:6056-6056(1991).
[27]	VARIANT NASHVILLE/ANAHEIM HIS-392. PubMed=1536798 [NCBI, ExPASy, EBI, Israel, Japan] Filosa S., Calabro V., Vallone D., Poggi V., Mason P., Pagnini D., Alfinito F., Rotoli B., Martini G., Luzzatto L., Battistuzzi G.; "Molecular basis of chronic non-spherocytic haemolytic anaemia: a new G6PD variant (393arg-to-his) with abnormal K(m) G6P and marked in vivo instability."; Br. J. Haematol. 80:111-116(1992).
[28]	VARIANT CHINESE-2/MAEWO CYS-453. PubMed=1303180 [NCBI, ExPASy, EBI, Israel, Japan] Perng L.-I., Chiou S.-S., Liu T.-C., Chang J.-G.; "A novel C to T substitution at nucleotide 1360 of cDNA which abolishes a natural Hha I site accounts for a new G6PD deficiency gene in Chinese."; Hum. Mol. Genet. 1:205-205(1992).
[29]	VARIANT KALYAN/KERALA LYS-316. PubMed=1303182 [NCBI, ExPASy, EBI, Israel, Japan] Ahluwalia A., Corcoran C.M., Vulliamy T.J., Ishwad C.S., Naidu J.M., Stevens D.J., Mason P.J., Luzzatto L.; "G6PD Kalyan and G6PD Kerala; two deficient variants in India caused by the same 317 Glu-->Lys mutation."; Hum. Mol. Genet. 1:209-210(1992).
[30]	VARIANT AURES THR-47. PubMed=8490627 [NCBI, ExPASy, EBI, Israel, Japan] Nafa K., Reghis A., Osmani N., Baghli L., Benabadji M., Kaplan J.-C., Vulliamy T.J., Luzzatto L.; "G6PD Aures: a new mutation (48 Ile-->Thr) causing mild G6PD deficiency is associated with favism."; Hum. Mol. Genet. 2:81-82(1993).
[31]	VARIANT SHINSHU GLY-175. PubMed=8193373 [NCBI, ExPASy, EBI, Israel, Japan] Hirono A., Miwa S., Fujii H., Ishida F., Yamada K., Kubota K.; "Molecular study of eight Japanese cases of glucose-6-phosphate dehydrogenase deficiency by nonradioisotopic single-strand conformation polymorphism analysis."; Blood 83:3363-3368(1994).
[32]	VARIANT BARI LEU-395. DOI=10.1007/BF00211027; PubMed=7959695 [NCBI, ExPASy, EBI, Israel, Japan] Filosa S., Cai W., Galanello R., Cao A., de Mattia D., Schettini F., Martini G.; "A novel single-base mutation in the glucose 6-phosphate dehydrogenase gene is associated with chronic non-spherocytic haemolytic anaemia."; Hum. Genet. 94:560-562(1994).
[33]	VARIANTS NAMORU; VANUA LAVA; NAONE AND UNION. PubMed=7825590 [NCBI, ExPASy, EBI, Israel, Japan] Ganczakowski M., Town M., Bowden D.K., Vulliamy T.J., Kaneko A., Clegg J.B., Weatherall D.J., Luzzatto L.; "Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific)."; Am. J. Hum. Genet. 56:294-301(1995).
[34]	VARIANT ORISSA GLY-43. PubMed=8533762 [NCBI, ExPASy, EBI, Israel, Japan] Kaeda J.S., Chhotray G.P., Ranjit M.R., Bautista J.M., Reddy P.H., Stevens D., Naidu J.M., Britt R.P., Vulliamy T.J., Luzzatto L., Mason P.J.; "A new glucose-6-phosphate dehydrogenase variant, G6PD Orissa (44 Ala-->Gly), is the major polymorphic variant in tribal populations in India."; Am. J. Hum. Genet. 57:1335-1341(1995).
[35]	VARIANTS SWANSEA PRO-74; PLYMOUTH ASP-162; CORUM LYS-273 AND WEXHAM PHE-277. PubMed=7858267 [NCBI, ExPASy, EBI, Israel, Japan] Mason P.J., Sonati M.F., Macdonald D., Lanza C., Busutil D., Town M., Corcoran C.M., Kaeda J.S., Stevens D.J., Al-Ismail S., Altay C., Hatton C., Lewis D.S., McMullin M.F., Meloni T., Paul B., Pippard M., Prentice A.G., Vulliamy T.J., Luzzatto L.; "New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia."; Blood 85:1377-1380(1995).
[36]	VARIANTS MOUNT SINAI ASP-125 AND CYS-386. PubMed=9452072 [NCBI, ExPASy, EBI, Israel, Japan] Vlachos A., Westwood B., Lipton J.M., Beutler E.; "G6PD Mount Sinai: a new severe hemolytic variant characterized by dual mutations at nucleotides 376G and 1159T (N126D)."; Hum. Mutat. Suppl. 1:S154-S155(1998).
[37]	VARIANT SINNAI LEU-11. DOI=10.1002/(SICI)1098-1004(1998)12:1<72::AID-HUMU19>3.3.CO;2-K; PubMed=10627140 [NCBI, ExPASy, EBI, Israel, Japan] Galanello R., Loi D., Sollaino C., Dessi S., Cao A., Melis M.A.; "A new glucose 6 phosphate dehydrogenase variant, G6PD Sinnai (34 G->T)."; Hum. Mutat. 12:72-73(1998).
[38]	VARIANT REHOVOT HIS-321. DOI=10.1006/bcmd.2000.0334; PubMed=11112389 [NCBI, ExPASy, EBI, Israel, Japan] Iancovici-Kidon M., Sthoeger D., Abrahamov A., Volach B., Beutler E., Gelbart T., Barak Y.; "A new exon 9 glucose-6-phosphate dehydrogenase mutation (G6PD 'Rehovot') in a Jewish Ethiopian family with variable phenotypes."; Blood Cells Mol. Dis. 26:567-571(2000).

Comments

FUNCTION: Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.
CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP⁺ = D-glucono-1,5-lactone 6-phosphate + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway .
SUBUNIT: Homodimer or homotetramer.

ALTERNATIVE PRODUCTS:

Display all isoform sequences in FASTA format

Alternative splicing [2 named forms]

Name	Short
Isoform ID	P11413-1
This is the isoform sequence displayed in this entry.

Name	Long
Isoform ID	P11413-2
Features which should be applied to build the isoform sequence: VSP_001592.

TISSUE SPECIFICITY: The long isoform is found in lymphoblasts, granulocytes and sperm.
POLYMORPHISM: The sequence shown is that of variant B, the most common variant.
DISEASE: Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.
MISCELLANEOUS: Has NADP both as cofactor (bound to the N-teminal domain) and as structural element bound to the C-terminal domain.
SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.
DATABASE: NAME=G6PD; NOTE=G6PD deficiency resource; WWW="http://rialto.com/g6pd/".
DATABASE: NAME=G6PDdb; NOTE=G6PD mutation database; WWW="http://www.rubic.rdg.ac.uk/g6pd/".

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X03674; CAA27309.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65234; AAA63175.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M26749; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M26750; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65225; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65226; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65227; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65228; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65229; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65230; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65231; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65233; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M65232; AAA63175.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L44140; AAA92653.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X55448; CAA39089.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF277315; AAL27011.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000337; AAH00337.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M27940; AAA52504.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S58359; AAB26169.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X53815; CAA37811.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158096; AAN76367.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158097; AAN76368.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158098; AAN76369.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158099; AAN76370.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158100; AAN76371.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158101; AAN76372.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158102; AAN76373.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158103; AAN76374.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158104; AAN76375.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158105; AAN76376.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158106; AAN76377.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158107; AAN76378.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158108; AAN76379.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158109; AAN76380.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158110; AAN76381.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158111; AAN76382.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158112; AAN76383.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158113; AAN76384.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158114; AAN76385.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158115; AAN76386.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158116; AAN76387.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158117; AAN76388.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158118; AAN76389.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158119; AAN76390.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158120; AAN76391.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158121; AAN76392.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158122; AAN76393.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158123; AAN76394.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158124; AAN76395.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158125; AAN76396.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158126; AAN76397.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158127; AAN76398.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158128; AAN76399.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158129; AAN76400.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158130; AAN76401.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158131; AAN76402.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158132; AAN76403.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158133; AAN76404.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158134; AAN76405.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158135; AAN76406.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158136; AAN76407.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158137; AAN76408.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158138; AAN76409.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158139; AAN76410.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158140; AAN76411.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158141; AAN76412.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY158142; AAN76413.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M12996; AAA52499.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M23423; AAB59390.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M19866; AAA52501.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M21248; AAA52500.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S64462; AAB20299.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A40309; DEHUG6.

UniGene

Hs.461047

3D structure databases

PDB

1QKI; X-ray; A/B/C/D/E/F/G/H=1-514.

[ExPASy / RCSB / EBI]

ModBase

P11413.

Protein-protein interaction databases

DIP

P11413.

Enzyme and pathway databases

Reactome

P11413; -.

2D gel databases

SWISS-2DPAGE

P11413; HUMAN.

Organism-specific gene databases

HIX0017161; -.

HGNC:4057; G6PD.

G6PD; Homo sapiens.

305900; gene+phenotype. [NCBI / EBI]

HOVERGEN

[Family / Alignment / Tree]

Gene expression databases

CleanEx

HGNC:4057; G6PD.

Ontologies

GO:0004345;	Molecular function: glucose-6-phosphate 1-dehydrogenase activity (non-traceable author statement).
GO:0006010;	Biological process: glucose 6-phosphate utilization (traceable author statement).
GO:0006098;	Biological process: pentose-phosphate shunt (non-traceable author statement).
QuickGo view.

Family and domain databases

InterPro

IPR001282; G6PDH.
Graphical view of domain structure.

PANTHER

PTHR10097; G6PD; 1.
PTHR10097:SF2; G6PD; 1.

Pfam

PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000110; G6PD; 1.

PRINTS

PR00079; G6PDHDRGNASE.

ProDom

PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00871; zwf; 1.

PROSITE

PS00069; G6P_DEHYDROGENASE; 1.

BLOCKS

P11413.

Genome annotation databases

Ensembl

ENSG00000160211; Homo sapiens. [Contig view]

Other

G6PD; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Direct protein sequencing; Disease mutation; Glucose metabolism; Hereditary hemolytic anemia; NADP; Oxidoreductase; Phosphorylation; Polymorphism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`0 0`
`CHAIN`	`1 514`	`514`	`Glucose-6-phosphate 1-dehydrogenase.`	`PRO_0000068083`
`NP_BIND`	`38 44`	`7`	`NADP (By similarity).`
`ACT_SITE`	`262 262`		`Proton acceptor (By similarity).`
`BINDING`	`39 39`		`NADP (By similarity).`
`BINDING`	`71 71`		`NADP (By similarity).`
`BINDING`	`200 200`		`Substrate (By similarity).`
`BINDING`	`204 204`		`Substrate (By similarity).`
`BINDING`	`237 237`		`NADP.`
`BINDING`	`356 356`		`NADP.`
`BINDING`	`486 486`		`NADP.`
`MOD_RES`	`1 1`		`N-acetylalanine.`
`MOD_RES`	`400 400`		`Phosphotyrosine.`
`VARSPLIC`	`256 256`		`R -> RGPGRQGGSGSESCSLSLGSLVWGPHALEPGEQGGELRRA` `LASSVPR (in isoform Long).`	`VSP_001592`
`VARIANT`	`11 11`	`1`	`V -> L (in Sinnai).`	`VAR_002450`
`VARIANT`	`31 31`	`1`	`H -> R (in CSNA; Gahoe; class III; frequent in Chinese).`	`VAR_002451 [3D]`
`VARIANT`	`34 34`	`1`	`Missing (in CNSHA; Sunderland; class I).`	`VAR_002452`
`VARIANT`	`43 43`	`1`	`A -> G (in Orissa; class III; frequent in Indian tribal populations).`	`VAR_002453 [3D]`
`VARIANT`	`47 47`	`1`	`I -> T (in Aures; class II).`	`VAR_002454 [3D]`
`VARIANT`	`57 57`	`1`	`D -> N (in Metaponto; class III).`	`VAR_002455 [3D]`
`VARIANT`	`67 67`	`1`	`V -> M (in A(-) type I; class III; frequent in African population; dbSNP:1050828) [NCBI/Ensembl].`	`VAR_002456 [3D]`
`VARIANT`	`69 69`	`1`	`Y -> H (in Namoru; 4% activity).`	`VAR_002457 [3D]`
`VARIANT`	`74 74`	`1`	`L -> P (in Swansea; class I).`	`VAR_002458 [3D]`
`VARIANT`	`80 80`	`1`	`R -> C (in Konan/Ube; class III).`	`VAR_002460 [3D]`
`VARIANT`	`80 80`	`1`	`R -> H (in Lagosanto; class III).`	`VAR_002459 [3D]`
`VARIANT`	`105 105`	`1`	`S -> C (in Vancouver; class I).`	`VAR_002461 [3D]`
`VARIANT`	`125 125`	`1`	`N -> D (in A(+), A(-), Santa Maria; class IV and in Mount Sinai; class I; dbSNP:1050829) [NCBI/Ensembl].`	`VAR_002462 [3D]`
`VARIANT`	`127 127`	`1`	`L -> P (in Vanua Lava; 4% activity).`	`VAR_002463 [3D]`
`VARIANT`	`130 130`	`1`	`G -> V (in Chinese-4).`	`VAR_002464 [3D]`
`VARIANT`	`155 155`	`1`	`E -> K (in Ilesha; class III).`	`VAR_002465 [3D]`
`VARIANT`	`162 162`	`1`	`G -> D (in Plymouth; class I).`	`VAR_002467 [3D]`
`VARIANT`	`162 162`	`1`	`G -> S (in Mahidol; class III).`	`VAR_002466 [3D]`
`VARIANT`	`164 164`	`1`	`N -> D (in Chinese-3; class II).`	`VAR_002468 [3D]`
`VARIANT`	`165 165`	`1`	`R -> H (in Naone; 1% activity).`	`VAR_002469 [3D]`
`VARIANT`	`175 175`	`1`	`D -> G (in Shinshu; class I).`	`VAR_002470 [3D]`
`VARIANT`	`180 180`	`1`	`D -> V (in Santa Maria; class I).`	`VAR_002471 [3D]`
`VARIANT`	`181 181`	`1`	`R -> W (in Vancouver; class I).`	`VAR_002472 [3D]`
`VARIANT`	`187 187`	`1`	`S -> F (in Sassari/Cagliari; class II; frequent in the Mediterranean).`	`VAR_002473 [3D]`
`VARIANT`	`197 197`	`1`	`R -> C (in Coimbra; class II).`	`VAR_002474 [3D]`
`VARIANT`	`197 197`	`1`	`R -> P (in CNSHA; Santiago; class I).`	`VAR_002475 [3D]`
`VARIANT`	`211 211`	`1`	`M -> V (in Sibari; class III).`	`VAR_002476 [3D]`
`VARIANT`	`212 212`	`1`	`V -> L (in Minnesota; class I).`	`VAR_002477 [3D]`
`VARIANT`	`215 215`	`1`	`F -> L (in Harilaou; class I).`	`VAR_002478 [3D]`
`VARIANT`	`226 226`	`1`	`R -> L (in A- type 2; class III).`	`VAR_002480 [3D]`
`VARIANT`	`226 226`	`1`	`R -> Q (in Mexico City; class III).`	`VAR_002479 [3D]`
`VARIANT`	`241 242`	`2`	`Missing (in Stonybrook; class I).`	`VAR_002481`
`VARIANT`	`256 256`	`1`	`R -> G (in Wayne; class I).`	`VAR_002482 [3D]`
`VARIANT`	`273 273`	`1`	`E -> K (in Corum; class I).`	`VAR_002483 [3D]`
`VARIANT`	`277 277`	`1`	`S -> F (in Wexham; class I).`	`VAR_002484 [3D]`
`VARIANT`	`278 278`	`1`	`T -> S (in Chinese-1; class II).`	`VAR_002485 [3D]`
`VARIANT`	`281 281`	`1`	`D -> H (in Seattle; class III).`	`VAR_002486 [3D]`
`VARIANT`	`284 284`	`1`	`R -> H (in Montalbano; class III).`	`VAR_002487 [3D]`
`VARIANT`	`290 290`	`1`	`V -> M (in Viangchan/Jammu; class II).`	`VAR_002488 [3D]`
`VARIANT`	`316 316`	`1`	`E -> K (in Kalyan/Kerala; class III).`	`VAR_002489 [3D]`
`VARIANT`	`321 321`	`1`	`Y -> H (in Rehovot).`	`VAR_020535 [3D]`
`VARIANT`	`322 322`	`1`	`L -> P (in A- type 3; class III).`	`VAR_002490 [3D]`
`VARIANT`	`334 334`	`1`	`A -> T (in Chatham; class III).`	`VAR_002491 [3D]`
`VARIANT`	`341 341`	`1`	`L -> F (in Chinese-5).`	`VAR_002492 [3D]`
`VARIANT`	`352 352`	`1`	`P -> S (in Ierapetra; class II).`	`VAR_002493 [3D]`
`VARIANT`	`362 362`	`1`	`N -> K (in Loma Linda; class I).`	`VAR_002494 [3D]`
`VARIANT`	`384 384`	`1`	`C -> R (in Tomah; class I).`	`VAR_002495 [3D]`
`VARIANT`	`385 385`	`1`	`K -> E (in Iowa; class I).`	`VAR_002496 [3D]`
`VARIANT`	`386 386`	`1`	`R -> C (in CNSHA; Guadajalara and Mount Sinai; class I).`	`VAR_002498 [3D]`
`VARIANT`	`386 386`	`1`	`R -> H (in Beverly Hills; class I).`	`VAR_002497 [3D]`
`VARIANT`	`392 392`	`1`	`R -> H (in Nashville/Anaheim; class I).`	`VAR_002499 [3D]`
`VARIANT`	`393 393`	`1`	`V -> L (in CNSHA; Alhambra; class I).`	`VAR_002500 [3D]`
`VARIANT`	`395 395`	`1`	`P -> L (in Bari; class I).`	`VAR_002501 [3D]`
`VARIANT`	`397 397`	`1`	`E -> K (in Puerto Limon; class I).`	`VAR_002502 [3D]`
`VARIANT`	`409 409`	`1`	`G -> C (in Riverside; class I).`	`VAR_002503 [3D]`
`VARIANT`	`409 409`	`1`	`G -> D (in CNSHA; Japan; class I).`	`VAR_002504 [3D]`
`VARIANT`	`415 415`	`1`	`E -> K (in Tokyo; class I).`	`VAR_002505 [3D]`
`VARIANT`	`438 438`	`1`	`R -> P (in CNSHA; Pawnee; class I).`	`VAR_002506 [3D]`
`VARIANT`	`439 439`	`1`	`L -> F (in Telti/Kobe; class I).`	`VAR_002507 [3D]`
`VARIANT`	`446 446`	`1`	`G -> R (in Santiago de Cuba; class I).`	`VAR_002508 [3D]`
`VARIANT`	`448 448`	`1`	`Q -> H (in Cassano; class II).`	`VAR_002509 [3D]`
`VARIANT`	`453 453`	`1`	`R -> C (in Chinese-II/Maewo/Union; class II, <1% activity).`	`VAR_002510 [3D]`
`VARIANT`	`453 453`	`1`	`R -> H (in Andalus; class I).`	`VAR_002511 [3D]`
`VARIANT`	`458 458`	`1`	`R -> L (in Canton; class II; frequent in China).`	`VAR_002512 [3D]`
`VARIANT`	`458 458`	`1`	`R -> P (in Cosenza; class II).`	`VAR_002513 [3D]`
`VARIANT`	`462 462`	`1`	`R -> H (in Kaiping; class II).`	`VAR_002514 [3D]`
`VARIANT`	`487 487`	`1`	`G -> V (in Campinas; class I).`	`VAR_002515 [3D]`
`CONFLICT`	`10 10`		`H -> Q (in Ref. 5, 7 and 8).`
`CONFLICT`	`434 435`		`DA -> EP (in Ref. 12).`
`STRAND`	`28 28`	`1`
`STRAND`	`31 36`	`6`
`TURN`	`37 39`	`3`
`STRAND`	`40 40`	`1`
`HELIX`	`41 45`	`5`
`TURN`	`46 46`	`1`
`HELIX`	`47 56`	`10`
`TURN`	`57 58`	`2`
`STRAND`	`60 60`	`1`
`STRAND`	`62 72`	`11`
`STRAND`	`75 75`	`1`
`TURN`	`77 79`	`3`
`HELIX`	`80 83`	`4`
`STRAND`	`84 84`	`1`
`TURN`	`87 88`	`2`
`HELIX`	`91 101`	`11`
`TURN`	`102 103`	`2`
`STRAND`	`104 105`	`2`
`STRAND`	`108 108`	`1`
`TURN`	`111 112`	`2`
`HELIX`	`114 126`	`13`
`TURN`	`127 132`	`6`
`STRAND`	`133 139`	`7`
`STRAND`	`141 141`	`1`
`HELIX`	`143 156`	`14`
`STRAND`	`157 157`	`1`
`STRAND`	`160 162`	`3`
`STRAND`	`164 169`	`6`
`STRAND`	`174 174`	`1`
`HELIX`	`176 189`	`14`
`STRAND`	`190 190`	`1`
`HELIX`	`192 194`	`3`
`STRAND`	`195 197`	`3`
`HELIX`	`200 203`	`4`
`STRAND`	`204 204`	`1`
`HELIX`	`205 215`	`11`
`STRAND`	`216 216`	`1`
`STRAND`	`218 218`	`1`
`TURN`	`219 223`	`5`
`STRAND`	`224 225`	`2`
`TURN`	`226 228`	`3`
`STRAND`	`229 237`	`9`
`STRAND`	`239 240`	`2`
`STRAND`	`244 244`	`1`
`HELIX`	`246 249`	`4`
`TURN`	`250 252`	`3`
`HELIX`	`253 257`	`5`
`TURN`	`258 261`	`4`
`HELIX`	`262 271`	`10`
`STRAND`	`276 278`	`3`
`HELIX`	`280 291`	`12`
`TURN`	`292 293`	`2`
`STRAND`	`294 294`	`1`
`HELIX`	`299 301`	`3`
`STRAND`	`302 308`	`7`
`TURN`	`311 312`	`2`
`STRAND`	`313 313`	`1`
`HELIX`	`315 318`	`4`
`STRAND`	`321 321`	`1`
`TURN`	`322 323`	`2`
`TURN`	`325 326`	`2`
`STRAND`	`327 327`	`1`
`TURN`	`329 330`	`2`
`STRAND`	`335 343`	`9`
`STRAND`	`345 345`	`1`
`TURN`	`346 350`	`5`
`STRAND`	`352 360`	`9`
`STRAND`	`362 362`	`1`
`STRAND`	`365 372`	`8`
`STRAND`	`376 377`	`2`
`STRAND`	`379 380`	`2`
`TURN`	`381 382`	`2`
`STRAND`	`388 396`	`9`
`STRAND`	`398 406`	`9`
`STRAND`	`408 410`	`3`
`STRAND`	`413 422`	`10`
`HELIX`	`423 426`	`4`
`TURN`	`427 427`	`1`
`STRAND`	`429 429`	`1`
`HELIX`	`435 445`	`11`
`TURN`	`446 446`	`1`
`HELIX`	`448 450`	`3`
`STRAND`	`451 452`	`2`
`HELIX`	`454 474`	`21`
`STRAND`	`479 482`	`4`
`TURN`	`483 484`	`2`
`STRAND`	`485 485`	`1`
`HELIX`	`489 497`	`9`
`TURN`	`498 499`	`2`
`STRAND`	`504 504`	`1`

Sequence information

Length: 514 AA [This is the length of the unprocessed precursor]

Molecular weight: 59135 Da [This is the MW of the unprocessed precursor]

CRC64: F6A11CB092B0A96F [This is a checksum on the sequence]

        10         20         30         40         50         60 
AEQVALSRTH VCGILREELF QGDAFHQSDT HIFIIMGASG DLAKKKIYPT IWWLFRDGLL 

        70         80         90        100        110        120 
PENTFIVGYA RSRLTVADIR KQSEPFFKAT PEEKLKLEDF FARNSYVAGQ YDDAASYQRL 

       130        140        150        160        170        180 
NSHMNALHLG SQANRLFYLA LPPTVYEAVT KNIHESCMSQ IGWNRIIVEK PFGRDLQSSD 

       190        200        210        220        230        240 
RLSNHISSLF REDQIYRIDH YLGKEMVQNL MVLRFANRIF GPIWNRDNIA CVILTFKEPF 

       250        260        270        280        290        300 
GTEGRGGYFD EFGIIRDVMQ NHLLQMLCLV AMEKPASTNS DDVRDEKVKV LKCISEVQAN 

       310        320        330        340        350        360 
NVVLGQYVGN PDGEGEATKG YLDDPTVPRG STTATFAAVV LYVENERWDG VPFILRCGKA 

       370        380        390        400        410        420 
LNERKAEVRL QFHDVAGDIF HQQCKRNELV IRVQPNEAVY TKMMTKKPGM FFNPEESELD 

       430        440        450        460        470        480 
LTYGNRYKNV KLPDAYERLI LDVFCGSQMH FVRSDELREA WRIFTPLLHQ IELEKPKPIP 

       490        500        510 
YIYGSRGPTE ADELMKRVGF QYEGTYKWVN PHKL

P11413 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools